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1.
Arq. bras. neurocir ; 37(2): 105-112, 24/07/2018.
Article in English | LILACS | ID: biblio-912236

ABSTRACT

Introduction Schwannomas and neurofibromas are the two most common benign neoplasms of the peripheral nerve sheath, and although they are generally easy to distinguish, in some cases, they can closely resemble one another. Furthermore, malignant peripheral nerve sheath tumors (MPNSTs), another example of peripheral nerve sheath neoplasm, may likewise constitute, due to their morphology and lack of specific immunohistochemical markers, a challenging diagnostic. Objective To bring attention to new and promising biomarkers for schwannomas, neurofibromas and MPNSTs and to outline, based on the recent literature, a immunohistochemical profile for each neoplasm at hand, as well as to emphasize the need for further studies that could help us understand their diagnostic potential and disrupt our dependence of limited and nonspecific biomarkers. Methods An overview of the recent literature published in English on both the classical promising immunohistochemical markers of schwannomas, neurofibromasand MPNSTs was performed. We discarded case reports. Conclusions There is still a lack of specific biomarkers for peripheral nerve tumors. However, plenty of new immunohistochemical markers have been coming to light with presumed higher specificity and more diverse helpful uses than the classical ones. For example, Sox10 is a good biomarker for differentiating schwannomas and neurofibromas from sarcomas, calretinin schwannomas from neurofibromas, TLE1 and HMGA2 MPNSTs from sarcomas, and nestin, EGFR, p16 and Ki-67 MPNSTs from different types of schwannomas and neurofibromas. There is still need for further studies; however, the potential of some of these promising markers, among others, should not be disregarded.


Introdução Schwannomas e neurofibromas são as duas neoplasias benignas mais comuns a acometer o tecido nervoso periférico, e apesar de geralmente serem facilmente distinguíveis, em alguns casos, elas podem ser muito semelhantes. Além disso, os tumores malignos da bainha dos nervos periféricos (TMBNPs), outro exemplo de neoplasia da bainha do nervo periférico, podem da mesma forma constituir, pela sua morfologia e falta de marcadores imuno-histoquímicos específicos, um diagnóstico desafiador. Objetivo Chamar a atenção para novos e promissores biomarcadores para schwannomas, neurofibromas e TMBNPs e delinear, a partir da literatura atual, um perfil imuno-histoquímico para cada neoplasia em questão, além de enfatizar a necessidade de futuros estudos que possam elucidar-nos acerca de seu potencial diagnóstico e, por ventura, romper nossa dependência de biomarcadores inespecíficos e limitados. Método Foi feita uma revisão da literatura recente incluindo artigos em língua inglesa sobre os marcadores imunohistoquímicos clássicos e os promissores para schwannomas, neurofibromas e TMBNPs. Descartamos relatos de caso. Conclusão Ainda há uma falta de biomarcadores específicos para as neoplasias acima. Contudo, vários novos marcadores imuno-histoquímicos têm surgido, e com futuros estudos poderemos talvez definir biomarcadores específicos e indispensáveis para os casos desafiadores de neurofibromas, schwannomas e TMBNPs. Por exemplo, o Sox10 é um bom biomarcador para diferenciar schwannomas e neurofibromas de sarcomas; a calretinina é um bom marcador para diferenciar schwannomas de neurofibromas; os biomarcadores TLE1 e HMGA2 podem ajudar a diferenciar TMBNPs de sarcomas, e a nestina, o receptor do fator de crescimento epidérmico (EGFR), o gene p16 e a proteína Ki-67 podem diferenciar TMBNPs de diferentes tipos de schwannomas e neurofibromas. Ainda há necessidade de novos estudos; contudo, o potencial de alguns desses marcadores, dentre outros, não deveria ser negligenciado.


Subject(s)
Humans , Nerve Sheath Neoplasms , Neoplasms, Nerve Tissue , Neurilemmoma , Neurofibroma , Immunohistochemistry
2.
VozAndes ; 24(1-2): 75-78, 2013.
Article in Spanish | LILACS | ID: biblio-1015733

ABSTRACT

La neurofbromatosis puede englobarse dentro del grupo de las llamadas enfermedades raras. La expresión clínica de la neurofbromatosis tipo 1 (NF-1) es variable, desde pequeños neurofbromas dérmicos y pigmentación anormal, hasta grotescos neurofbromas plexiformes y displasias óseas que interferen con la función de órganos o alteran la apariencia del individuo. Entre la población que sufre la enfermedad son cinco veces más frecuentes las difcultades del aprendizaje. A pesar de que la clínica de la NF-1 tiene un amplio espectro, para plantear que un paciente es portador de esta enfermedad hereditaria se considera la presencia de dos o más criterios establecidos: seis o más máculas color "café con leche", dos o más neurofbromas de cualquier tipo o un neurofbroma plexiforme, una lesión ósea distintiva, dos o más nódulos de Lisch, glioma del nervio óptico, efélides axilares o inguinales, familiar con NF-1 en primer grado relativo [2]. Otras manifestaciones clínicas a considerar y que pueden verse en la NF-1 son: tumores asociados a vainas no neurales, retardo mental o coefciente de inteligencia menor de 70 con respecto a la población en general, disfunción endocrina (como defciencia de GH y pubertad precoz en la ausencia de gliomas del quiasma óptico), hipertensión arterial, hidrocefalia, escoliosis. La TAC simple puede demostrar los neurofibromas bien definidos e hipodensos con respecto al músculo y la resonancia magnética es el método imagenológico más importante para determinar la localización, márgenes y relación de los tumores a las estructuras adyacentes. Hasta el momento no hay tratamiento médico ni quirúrgico específco para curar la neurofbromatosis, ni prevenir sus complicaciones. La actuación médica se limita a la detección temprana de las complicaciones y los pacientes deben ser tratados por un equipo interdisciplinario


Neurofbromatosis can be included in the group of calls rare diseases The clinical expression of neurofbromatosis type 1 (NF-1) is variable, from small dermal neurofbromas and abnormal pigmentation, to grotesque plexiform neurofbromas and dysplasias Bones that interfere with organ function or alter appearance of the individual. Among the population suffering from the disease are five times more frequent learning difficulties. Although the NF-1 clinic has a broad spectrum, for state that a patient is a carrier of this inherited disease the presence of two or more established criteria is considered: six or more "coffee with milk" macules, two or more neurofromas of any type or a plexiform neurofbroma, a distinctive bone lesion, two or more Lisch nodules, optic nerve glioma, axillary or inguinal ephelids, relative with NF-1 in relative first degree. Other manifestations Clinics to consider and that can be seen in NF-1 are: tumors associated to non-neural sheaths, mental retardation or intelligence coefficient less than 70 with respect to the general population, dysfunction endocrine (such as GH deficiency and precocious puberty in the absence of optic chiasma gliomas), arterial hypertension, hydrocephalus, scoliosis. Simple CT can demonstrate well-defined neurofibromas and hypodense with respect to muscle and magnetic resonance imaging is the most important imaging method to determine the location, margins and ratio of tumors to adjacent structures. So far there is no specific medical or surgical treatment to cure neurofbromatosis, or prevent its complications. Medical performance is limited to the early detection of complications and patients must be treated by an interdisciplinary team


Subject(s)
Humans , Primary Health Care , Neurofibromatoses , Neoplasms, Nerve Tissue , Rare Diseases , Diagnosis
3.
VozAndes ; 24(1-2): 79-82, 2013.
Article in Spanish | LILACS | ID: biblio-1015735

ABSTRACT

La neurofbromatosis de tipo 1 tiene una prevalencia de un caso en cada 2500 a 3000 personas. Es una enfermedad autosómica dominante que presenta básicamente ausencia de una proteína llamada neurofibromina, codificada en el gen del mismo nombre. Al estar el gen mutado la neurofbromina pierde su capacidad supresora tumoral. Se ha asociado la neurofbromatosis con riesgo elevado de cáncer de la vaina nerviosa y con cáncer de colon además de formación de tumores de cualquier naturaleza. Existen básicamente 6 criterios de diagnóstico para la neurofbromatosis: 1) presencia de seis o más manchas de color "café con leche"; 2) dos o más neurofibromas de cualquier tipo o al menos un neurofibroma plexiforme; 3) efélides axilares e inguinales; 4) glioma óptico; 5) dos o más nódulos de Lisch (hamartomas del iris); 6) al menos un familiar en primer grado de consanguinidad que tenga neurofbromatosis tipo 1


Type 1 neurofbromatosis has a prevalence of a case in Every 2500 to 3000 people. It is an autosomal dominant disease which basically presents the absence of a protein called neurofibromin, encoded in the gene of the same name. Being the gene mutated neurofbromin loses its tumor suppressor capacity. He has associated neurofbromatosis with a high risk of cancer of the nerve sheath and with colon cancer in addition to tumor formation of any nature. There are basically 6 diagnostic criteria for neurofbromatosis: 1) presence of six or more "coffee with milk" spots; 2 two or more neurofibromas of any type or at least one neurofibroma plexiform; 3) axillary and inguinal ephelids; 4) optical glioma; 5) two or more Lisch nodules (iris hamartomas); 6) at least one relative in first degree of consanguinity that has neurofbromatosis type 1


Subject(s)
Humans , Neurofibromatoses , Neoplasms, Nerve Tissue , Neurofibroma , Case Reports , Ecuador
4.
Arch. venez. pueric. pediatr ; 74(3): 112-117, sep. 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-659182

ABSTRACT

La esclerosis tuberosa (ET) es una anomalía genética, multisistémica, susceptible de originar tumores del sistema nervioso central. Las crisis epilépticas son manifestaciones comunes y constituyen el principal problema terapéutico. Describir lascaracterísticas epilépticas de los pacientes pediátricos con diagnóstico de complejo de esclerosis tuberosa (CET), controlados en el Servicio de Neurología Pediátrica del Instituto Autónomo Hospital Universitario de los Andes. Se realizó un estudio observacional, retrospectivo, tipo serie de casos con ET y Epilepsia. Se describió sexo, edad de diagnóstico e inicio de crisis, motivo de consulta, tipo de crisis epiléptica, hallazgos electroencefalográficos y de imagen, asociación a trastornos conductuales, severidad de compromiso intelectual y manifestaciones dermatológicas. Doce pacientes cumplieron criterios diagnósticos de CET, 10 (83%) fueron epilépticos, deéstos el 50% cursó con epilepsia de difícil control, 60% tuvo crisis parciales, 40% generalizadas. El 100% mostró alteraciones electroencefalográficas, 30% con patrón hipsarrítmico. 50% tenían alteraciones estructurales, tipo túber cortical en 80%. En 70% secontrolaron las crisis con Acido Valpróico y en un caso se requirió dieta cetogénica estricta. El signo extraneurológico más constante fueronmáculas hipocrómicas (100%). Aunque las convulsiones no forman parte de los criterios diagnósticos, son el motivo másfrecuente de consulta, que en asociación con máculas hipocrómicas, hace sospechar diagnóstico de ET. La variedad, refractariedad e inicio temprano de crisis requieren en muchos casos politerapia para el control, lo cual favorece el pronóstico del paciente


Tuberous sclerosis (TS) is a genetic, multisystemic, likely to cause central nervous system tumors. Seizures are common manifestations are the main therapeutic problem. To describe the epileptic characteristics, of pediatric patients with diagnosed with tuberous sclerosis complex (TSC), controlled in the Pediatric Neurology Department University Hospital Institute of Los Andes. Was performed an observational, retrospective, case series, with ET and Epilepsy. Described: sex, age of the diagnosis and initiation of crisis, reason for visit, seizure type, electroencephalographic findings and images, behavioral disorders, severity ofintellectual engagement and dermatologic manifestations. Twelve patients met the criteria diagnostic CET, 10 (83%) were epileptic, of these 50% passed with epilepsy of difficult control. 60% had partial seizures (40%) generalized. The 100% showed EEGabnormalities, hypsarrhythmic pattern 30% . The 50% of cases had structural abnormalities, 80% cortical tuber type. In 70% was achieved crisis control with valproic acid and in one case was required strict ketogenic diet .The extraneurological sign more constantwere the hypochromic macules (100%). Conclusion: Although seizures are not part of the diagnostic criteria, are the most frequent reason for consultation in partnership with hypochromic macules to suspect a diagnosis of ET. The variety, refractoriness and early onset of crisis, often require polytherapy to control, which favors the patient's prognosis.


Subject(s)
Humans , Male , Female , Child , Seizures/complications , Seizures/diagnosis , Tuberous Sclerosis/congenital , Neoplasms, Nerve Tissue , Neurology , Epilepsy , Pediatrics , Nervous System/physiopathology
6.
Article in English | IMSEAR | ID: sea-44096

ABSTRACT

OBJECTIVE: To present results of intra-operative consultation in surgical neuropathology and discuss the diagnostic guideline for squash cytology. MATERIAL AND METHOD: The intra-operative pathological diagnosis of 120 neurosurgical specimens was compared with the final histologic diagnosis. Squash preparation was used solely in 83 cases, frozen sections alone in 3 cases, and both techniques in the remaining. An algorithm for cytologic diagnosis was described. RESULTS: The intra-operative pathological diagnoses in neurosurgery were completely (83%) and partially (13%) correlated with the final results. CONCLUSIONS: Intra-operative diagnosis in surgical neuropathology is reliable. Squash cytology is highly recommended as an alternative approach.


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Cytological Techniques , Female , Frozen Sections , Humans , Infant , Intraoperative Period , Male , Middle Aged , Neoplasms, Nerve Tissue/pathology , Nervous System Neoplasms/pathology
7.
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2003; 13 (6): 333-6
in English | IMEMR | ID: emr-62564

ABSTRACT

To assess the role of cerebrospinal fluid diversion in posterior fossa tumor surgery. Design: Descriptive study. Place and Duration of Study: This study was conducted at the Department of Neurosurgery, Pakistan Institute of Medical Sciences [PIMS], Islamabad from February 2000 to July 2002 over a period of two and-a-half years. Subjects and Clinical, radiological and operative records of the patients who were operated for posterior fossa tumors were studied. Absolute and relative frequencies of the patients who were managed with external ventricular drainage [EVD] or ventriculoperitoneal shunt [VPS] were determined. Mean age and male to female ratio were also noted. There were 48 patients who were operated for posterior fossa tumors. Mean age was 23 years. Male to female ratio was 1.2:1. VPS was done in 14 patients [29%] pre-operatively, in one patient [2%] per-operatively and in 2 patients [4%] postoperatively. EVD was done in 33 patients out of whom 2 patients were shunted post-operatively. Sixty-five% of the patients remained shunt-free. Although management of hydrocephalus secondary to posterior fossa tumors is controversial, majority of the patients need temporary cerebrospinal fluid diversion


Subject(s)
Humans , Male , Female , Cerebrospinal Fluid Shunts/methods , Neoplasms, Nerve Tissue/surgery , Infratentorial Neoplasms/complications , Neoplasms, Nerve Tissue/complications , Hydrocephalus/etiology , Hydrocephalus/surgery
8.
Indian J Pathol Microbiol ; 1997 Oct; 40(4): 515-9
Article in English | IMSEAR | ID: sea-75905

ABSTRACT

Soft tissue tumours of eyelid constituted 28.9% of all eyelid tumours. Morphologically they were either vascular 32 cases (49.23%), neural 24 cases (36.92%), fibrous 6 cases (9.23%) or adipose tissue tumours 3 cases (4.62%). The age ranged from 1-30 years, haemangiomas and neurofibromas were present since birth. Upper eyelid was involved in 81.54% cases. Neurofibroma was associated with generalized lesions in 13.6% cases.


Subject(s)
Adipose Tissue , Adult , Age of Onset , Child , Eyelid Neoplasms/pathology , Female , Hemangioma/pathology , Humans , Male , Neoplasms, Nerve Tissue/pathology , Neurofibroma/pathology , Retrospective Studies , Soft Tissue Neoplasms/pathology , Vascular Neoplasms/pathology
10.
Maghreb Medical. 1997; (311): 19-20
in French | IMEMR | ID: emr-45337
11.
Córdoba; s.n; 1994. 161 p. ilus.
Thesis in Spanish | LILACS | ID: lil-243283

ABSTRACT

RESUMEN: El OBJETIVO de nuestro trabajo fue comparar dos métodos diagnóstico y demostrar las semejanzas de las distinas Clasificaciones de los Tumores Gliales del Sistema Nervioso Central. Fue necesario realizar técnicas de inmunomarcación para proteína gliofibrilar ácida e impregnaciones argénticas para confrontar los hallazgos según las últimas interpretaciones histogenéticas. Estudiamos 95 Gliomas con hematoxilina-eosina y técnicas argénticas y en 58 casos realizamos además la técnica para proteína gliofibrilar ácida (GFAP). Con ambos métodos obtuvimos resultados iguales en el diagnóstico de tumores gliales cuyas calulas poseen gliofibrillas: Gliopiteliomas (Ependimomas), Glioblastomas, Astroblastomas y Astrocitomas. En los Oligodendrogliomas cuyas células no poseen gliofibrillas pero sí microtúbulos, las técnicas argenticas sirvieron para el diagnóstico al marcar las células y sus prolongaciones, no así la técnica para GFAP. También hay semejanzas al comparar la clasificación de Del Río Hortega-Polak con la de otros autores referente a los Gliomas. Sólo hay diferencias en la nomenclatura de lagunos tumores o en su interpretación histogenética que no son sustanciales y están limitados al "Espongioblastoma Polar" y al " Gliosarcoma", que interpretamos se deben a la no utilización de las impregnaciones argénticas. Por lo tanto cremos que la revalorización de la clasificación de Del Río Hortega-Polak está justificada.


Subject(s)
Central Nervous System Neoplasms , Neoplasms, Nerve Tissue
12.
Centro méd ; 39(1): 13-5, ene. 1993. ilus
Article in Spanish | LILACS | ID: lil-148164

ABSTRACT

Presentamos un caso de schwannoma cervical calcificado, en un paciente de 19 años de edad, cuyo motivo de consulta fue tumor cervical, localizado en la región lateral derecha del cuello. El día 15-08-88 fue intervenido quirúrgicamente, reaizando cervicotomía lateral derecha; los hallazgos correspondieron a un tumor sólido prevertebral, con relaciones en la base del cráneo, que desplazaba el esófago, la tráquea y el paquete vasculonervioso cervical derecho; fue resecado en su totalidad. Dada la laboriosa resección, lo difícil del diagnóstico diferencial y la baja frecuencia de esta lesión consideremos su reporte y la revisión de bibliografía nacional e internacional


Subject(s)
Adult , Humans , Male , Schwann Cells/pathology , Neoplasms, Nerve Tissue , Peripheral Nerves/pathology , Neurilemmoma/diagnosis , Neurilemmoma/pathology , Neurilemmoma/therapy , Neurofibroma , Peripheral Nervous System Neoplasms
13.
Sao Paulo; s.n; 1993. 101 p. ilus, tab.
Thesis in Portuguese | LILACS | ID: lil-135303

ABSTRACT

Para investigar as bases moleculares da reversao fenotipica induzida por hormonios glicocorticoides nas celulas C6/ST1, uma biblioteca de cDNA foi preparada a partir de celulas ST1 tratadas com hidrocortisona e o genes regulados por esse hormonio foram selecionados por hibridizacao diferencial.Genes do retrovirus, produzidos pelas celulas ST1 na presenca de hidrocortisona, foram isolados utilizando sondas preparada com RNA viral, 77 clones celulares foram isolados (74 induzidos e 3 reprimidos), hibridizacao cruzada revelou 15 clones com cDNAs diferentes (14 induzidos e um reprimido). Tres clones foram confirmados por Northern blot como induziveis por hidrocortisona. Dois deles (C27 e C41) correspondem aos genes da metalotioneina 1 e 2 (MT1 e MT2), respectivamente. O terceiro (C36) corresponde ao gene da alfa 1-glicoproteina acida (AGP). A expressao da MT1 e MT2 foi induzida nas celulas ST1 e P7 (linhagem resistente ao hormonio) enquanto a inducao da AGP foi detectada apenas nas celulas ST1. Dezoito clones retrovirais foram isolados e caracterizados como homologos. Um DLES (CV2), revelou corresponder ao gene "env" do retrovirus de leucemia de murinos endogeno. A expressao de c-sis e JE foi estudada nas celulas C6 e ST1 sendo esses genes reprimido nas duas linhagens. O presente estudo permitiu um melhor entendimento dos mecanismos moleculares envolvidos nessa reversao fenotipica


Subject(s)
Animals , Rats , Gene Expression Regulation/drug effects , Glioma/ultrastructure , Glucocorticoids/pharmacology , Neoplasms, Nerve Tissue , Phenotype , Molecular Biology
14.
Arq. neuropsiquiatr ; 50(2): 173-9, jun. 1992. ilus, tab
Article in Portuguese | LILACS | ID: lil-120727

ABSTRACT

Estudamos grupo de 198 casos de tumores neuroepiteliais com diagnóstico per-operatório feito pela análise citológica de esfregaços, comparando seus índices de acuidade com o diagnóstico final em cortes de parafina. Em 90,6% dos casos, o diagnóstico final obtido na parafina foi similar ao feito em esfregaços. No grupo de casos em que o diagnóstico citológico näo foi confirmado pelos cortes em parafina, na maioria dos casos näo foi afetada a conduta neurocirúrgica imediata, representando diferenças em graduaçäo de astrocitomas e gliomas mistos. Os critérios citológicos nos principais grupos de tumores säo apresentados, junto com as dificuldades para a interpretaçäo deste método valioso para diagnóstico per-operatório


Subject(s)
Humans , Neoplasms, Nerve Tissue/pathology , Nervous System Neoplasms/pathology , Culture Techniques , Cytodiagnosis , Glioma/pathology , Nervous System Neoplasms/classification
17.
HFA publ. téc. cient ; 5(1/2): 31-50, jan.-jun. 1990. tab, ilus
Article in Portuguese | LILACS | ID: lil-113903

ABSTRACT

Os tumores do mediatino em crianças apresentam algumas peculiaridades qye divergem dos adultos. O mediatino pode ser dividido em três compartimentos, o anterior, o médio e o posterior onde as lesöes se agrupam de modo preferencial. Os sintomas apresentados pelas crianças abaixo de dois anos de idade säo muito mais graves do que acima desta idade, salientado-se a compressäo traqueal em 78% dos casos. A incidência dos tumores mediatinais corresponde a 0.02% de todas as admissöes nos hospitais terciários. Quase 70% de todos os tumores nas crianças estäo representados por tumores do tipo neurogênico (35%), linfoma (20% e cisto enterógeno (13%). Um novo tipo de tumor (Askin) foi descrito recentemente e localizado no mediatino posterior. Foram descritos os estadiamentos da doença de Hodgkin e näo Hodgkin, bem como as formas de tratamento pela quimioterapia e radioterapia. Foi dada ênfase especial aos tumores do mediastino posterior, especialmente o neuroblastoma, cuja incidência no mediastino é de 20%, enquanto 70%, localiza-se no retroperítônio e 5% na pelvis. A classificaçäo mais adotada deste tipo de tumor é a de Evans. O prognóstico desta patologia no estágio I é excelente (100%), no estágio II (82%), estágio III (27,5%), estágio IV (15%) e estágio IVs, (80%)


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Lymphoma/diagnosis , Mediastinal Neoplasms/diagnosis , Neoplasms, Nerve Tissue/diagnosis , Lymphoma/epidemiology , Lymphoma/pathology , Mediastinal Neoplasms/epidemiology , Mediastinal Neoplasms/pathology , Neoplasm Staging , Neoplasms, Nerve Tissue/epidemiology , Neoplasms, Nerve Tissue/pathology , Prognosis , Tomography, X-Ray Computed
18.
Patología ; 28(2): 103-6, abr.-jun. 1990.
Article in Spanish | LILACS | ID: lil-102235

ABSTRACT

Se presenta un caso de schwanoma maligno con diferenciación rabdomioblástica (tumor "tritón" maligno, TTM) desarrollado en la pared costal de un niño de 4 años. La inesperada diferenciación divergente fue demostrada por inmunohistoquímica para proteína S-100, mioglobina, dismina y microscopía electrónica, ya que la histología convencional no había permitido su reconocimiento. La revisió de la literatura reunió otros 8 casos en niños, con gran dispersión en la edad y localización, pero en general con un pronótico desfavorable .


Subject(s)
Child, Preschool , Humans , Male , Cell Differentiation , Immunohistochemistry , Neoplasms, Nerve Tissue , Neurilemmoma/mortality , Neurilemmoma/pathology , Neurilemmoma/ultrastructure , Rhabdomyoma
19.
Patología ; 28(2): 107-9, abr.-jun. 1990. ilus
Article in English | LILACS | ID: lil-102236

ABSTRACT

Informamos de un caso de glioblastoma multiple congénito asociado a insuficiencia cardiaca derecha. Los hallazgos de autopsia se comparan con los informados en literatura y se suguiere que como en el caso del neuroblastoma y el retinoblastoma, los tumores gliales congénitos resultan de trastornos en los mecanismos que regulan la diferenciación celular. Se indican los obstáculos que pueden presentarse en el diagn tico de esta lesión .


Subject(s)
Humans , Male , Autopsy , Glioblastoma/diagnosis , Glioblastoma/physiopathology , Neoplasms, Nerve Tissue , Cell Differentiation , Heart Defects, Congenital
20.
Article in English | IMSEAR | ID: sea-16332

ABSTRACT

A series of 75 poorly differentiated neoplasms of the central nervous system viz., medullo-blastoma, cerebral neuroblastoma, pineoblastoma and ependymoblastoma were studied by light microscopy (LM), electron microscopy (EM) and immunohistochemistry (IH). Although the predominant cells constituting these tumours appeared to be undifferentiated cells by LM and EM, many others showed evidence of differentiation into glial, neuronal or ependymal cell lines by EM and IH. It is therefore, concluded that all these neoplasms are best considered as primitive neuroectodermal tumours and these may be classified as such in neuro-oncology. They may be subclassified further on the basis of differentiation into one or more cell lines.


Subject(s)
Brain Neoplasms/analysis , Glial Fibrillary Acidic Protein/analysis , Humans , Immunoenzyme Techniques , Neoplasms, Nerve Tissue/analysis , S100 Proteins/analysis
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